周艳芳

周艳芳

学院：基础医学院

专业：病理学与病理生理学

职称：教授

简介：

周艳芳（Yanfnang Zhou），医学博士，教授，硕士生导师，广东医科大学病理生理学教研室主任, 广东省高等学校“千百十工程”省级第八批培养对象，国家一流课程负责人（线上-线下混合式课程），广东省课程思政示范团队负责人、广东省研究生省级示范课程负责人，广东省网络学习空间应用普及活动优秀教师、广东医科大学教学名师，带领集体获得广东省巾帼文明岗，市三八红旗集体等荣誉称号。

科研致力于新型纳米载体联合干细胞移植促组织修复与再生的基础与应用转化研究。担任中国病理生理学免疫专业委员会青年委员，广东省病生学会委员。主持国家青年自然基金1项、广东省自然科学基金3项。2015年受国家留学基金委资助，公派南佛罗里达大学访学一年。以第一作者及通讯作者在Biomaterials 、Stem Cell and Development、Biomacromolecules等学术期刊发表SCI论文16篇, 最高影响因子12.5分，被引量200余次，最高被引量60次。获授权发明专利2项。

E-mail：yfzhou@gdmu.edu.cn

主持科研项目

1.突变型HIF-1a修饰MSC上调SDF-1分泌促进内源性CXCR4+神经干细胞向脑缺血损伤区迁移的机制研究（国家青年基金，NO:30901547）

2.HDAC6介导的PRDX2去乙酰化修饰在BMSCs促缺血性脑卒中神经修复的机制研究（广东省自然科学基金，NO：2021A1515012437）

3.皮肤创伤微环境中HDCA6-PRDX2去乙酰化修饰对BMSCs 命运转变的调控作用及机制（广东省教育厅普通高校科研项目，2021KTSCX040）

4.RVG29肽修饰的神经靶向基因载体跨血脑屏障作用及对缺血性脑损伤的修复(广东省社会发展领域科技计划项目NO: 2013B021800073)

5.神经靶向基因载体的构建及在脑缺血中的应用研究（广东省自然科学基金NO: S2012010008187）

6.表观遗传修饰BMSC结合皮肤支架促创伤修复的机制研究(广东省医学科学技术研究基金项目（No:B2018032）

7.内皮祖细胞促缺血性脑损伤血管发生中的机制研究（广东省医学科研基金NO: B2012265）

代表性成果

1. Wenwen Zhang, Tingyu Wang, Yuanye Xue1,Bingbing Zhan, Zengjie Lai, Wenjie Huang, Xinsheng Peng andYanfang Zhou.Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases.Front Immunol 2023;14

2. Jian-Peng Zhang, Zi-Duo Huang, Bing-Qing Wang, Yi-Xin Chen, Qing-Qing Zhou, Hui-Qin Li, Xin-Sheng Peng*,Yan-Fang Zhou*.An anti-aging skin strategy: promoting repair and regeneration in UV-induced photoaging micro-environment using growth factors-rich platelet lysates composite Self-protection Collagen Hydrogel.Biomedical Engineering Communications 2023;2(2):9

3. Xue Y, Gan B, Zhou Y, Wang T, Zhu T, Peng Xinsheng*,Zhang Xiangning*,Zhou Yanfang*. Advances in the Mechanistic Study

   of the Control of Oxidative Stress Injury by Modulating HDAC6 Activity. Cell Biochem Biophys.2023 Mar;81(1)

4. Yanfang Zhou, Wenen Liu, Bin Gan, Yuhui Wang, Zhiqiang Fan, Yucan Yang,Xin Xiong, Yuling Li, Huizhi Chen, Meng Yu, Xinsheng Peng4,*, and Yubin Zhou*.Non-cross-linked collagen type I microfibers for improved hemostasis and wound healing.Journal of Materials Science.2022,10.1007/s10853-022-07447-7.

5. Xin Yuan, Weihao Yuan（co-first author）, Lu Ding,Ming Shi,Liang Luo,Yong WanJiwon Oh ,Yanfang Zhou*, Liming Bian *, and David Y.B. Deng*.Cell-adaptable dynamic hydrogel reinforced with stem cells improves the functional repair of spinal cord injury by alleviating neuroinflammation.Biomaterials.2021,Dec;279:121190. doi: 10.1016/j.biomaterials.2021.121190. Epub 2021 Oct 20.(中科院分区一区[Top]，IF:12.5)

6. Zonggui Wang,Yanfang Zhou（co-first author）, Zhong Dai, Xiuju Chen, ChuyuLi,Zhanying Lin,HuixingWu,Siqi Li,Changqing Zuo* (correspondence).A Novel Long Noncoding RNA, Lnc-OAD,Is Required for Bone Morphogenetic Protein-2(BMP-2)InducedOsteoblast Differentiation.Biomed Res Int.2021 Mar 16;2021:6697749. doi: 10.1155/2021/6697749.eCollection 2021.(IF:3.4)

7. Biling Cui, Chenchen Zhang, Bin Gan, Wenen Liu, Jiaqiang Liang, Zhiqiang Fan, Yuying Wen, Yang Yang, Xinsheng Peng*,Yanfang Zhou*.Collagen-tussah silk fibroin hybrid scaffolds loaded with bone mesenchymal stem cells promote skin wound repair in rats.Mater Sci Eng C Mater Biol Appl.2020 Apr;109

8. Jia-Qiang Liang,Fang LU, Bin Gan, Yu-Ying Wen,Jin Chen,Huai-GaoWang, Yang Yang,Xin-Sheng Peng*,Yan-fang Zhou*.Low-dose Tubacin Promotes BMSCsProliferation and Morphological Changes Through the ERK Pathway.American Journal of Translational Research.2019,11(3):1446-1459

9. Peng# X.-s., Guo# C.-l., Fan Z.-q., Li Y.-l., Liu W.-e., Dai* Z.,Zhou Yanfang*(correspondence). Preparation and Characterization of Capsaicin-Collagen Sponge, Journal of Scientific&Technical Research 2019, 16(5): 12353-12360.

10. Xiaohui Zhu, Xin Wu, Jing Cheng, Hongbo Liao, Xiaoqing Di, Lili Li, Rong Li,Yanfang Zhou*(correspondence),Xiangning Zhang*.Dalbinol, a rotenoid from Amorpha fruticosa L,exerts anti-proliferative activity by facilitating β-catenin degradation in hepatocellular carcinoma cells.oncotarget,2017,8(29):47755-47766(IF:5.0)c,

11. Yanfang Zhou,Jiemei Li, Fang Lu,Junjie Deng,Jiahua Zhang,Peijie Fang,Xinsheng Peng*,Shu-Feng Zhou*.A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells.Drug Design, Development and Therapy,2015,9:2635-2645.

12. Xinsheng Peng,Yanfang Zhou（co-first author）,Ke Han,Lingzhen Qin,

    Linghui Dian,Ge Li,Xin Pan,Chuanbin Wu.Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin.Drug Design,Development andTherapy,2015,9:4209- 4218.

13. ZhouYanfang,GuoC,ChenH,ZhangY,PengX,ZhuP.DeterminationofSinomenineincubosomeanoparticlesbyHPLCtechnique.JournalofAnalyticalMethodsinChemistry,2015,doi:10.1155/2015/931687.（IF:0.79）

14. Huai-Gao Wang,Qing-Yun Wu,Hui Zhou, Xin-Sheng Peng, Meng-Jie Shi, Jie-Mei Li,Yan-Fan Zhou*(correspondence).The MDM2SNP309T>G

    Polymorphism IncreasesBladder Cancer Risk among Caucasians:a Meta-analysis.Asian Pac J Cancer Prev. 2014,15(13):5277-8.

15. Xinsheng Peng, Baohong Li, Min Hu, Yahao Ling, Yuan Tian, Yanxin Zhou,Yanfang Zhou*（correspondence）.Quantitative Analysis of Matrine in liquid crystalline nanoparticles by HPLC.Journal of Analytical Methods in Chemistry.2014 (368682)

16. Zhou Yanfang, Yang Bin, Ren Xianyue, Liu Zhenzhen, Deng Zheng, Chen Luming, Deng Yubin, Zhang Li-Ming, Yang Liqun.Hyperbranched cationic amylopectin derivatives for gene delivery.Biomaterials.2012，33(18):4731-40.

17. Qian Zhong,Yanfang Zhou（co-first author）, Weibiao Ye,Tuo Cai, Xiuquan Zhang,Yubin Deng.Hypoxia-inducible Factor 1-α-AA-modified Bone marrow stem cells protect PC12 cells from hypoxia-induced apoptosis, partially through VEGF/PI3K/Akt/FoxO1 pathway.Stem Cell and Development.2012,21(14):2703-17.