申志华
学院：基础医学院
专业：病理学与病理生理学
职称：教授
邮箱：shenzh@gdmu.edu.cn
简介：
申志华，女，博士，硕导，教授，广东医科大学病理生理学专任教师，从事肿瘤病理生理和心血管病理生理研究，主要研究领域为肿瘤侵袭转移机制及防治和心血管疾病基础与转化，获多项科研基金资助，以第一作者获通讯作者发表SCI论文多篇。
近5年承担的课题、发表的论文、获奖的成果、授权的专利等）
[1]国家自然科学基金地区基金项目，82060053，RhoE双相调控Nrf2-ARE信号在糖尿病心肌病氧化应激中的作用及机制研究，2021-01至2024-12，34万元，在研，参加
[2]国家自然科学基金面上项目，81670254，RhoE表达失调对心肌梗死后移植c-Kit+/Nkx2.5+骨髓间充质干细胞生物学功能的影响及机制，2017/01- 2021/12，直接经费57万元，结题，主要参与人
近5年发表的论文
[1]Zheng A, Bai J, Ha Y, Yu Y, Fan Y, Liang M, Lu Y,Shen Z, Luo B, Jie W. Integrated analysis of the relation to tumor immune microenvironment and predicted value of Stonin1 gene for immune checkpoint blockage and targeted treatment in kidney renal clear cell carcinoma. BMC Cancer. 2023 Feb 9;23(1):135.
[2]Bai J, Zheng A, Ha Y, Xu X, Yu Y, Lu Y, Zheng S,Shen Z, Luo B, Jie W. Comprehensive analysis of LAMC1 expression and prognostic value in kidney renal papillary cell carcinoma and clear cell carcinoma. Front Mol Biosci. 2022 Sep 16;9:988777.
[3]Wu C, Ha Y, Zou Y, Liao X, Zhang S, Zhang X, Li R, Xing J, Jie W, Guo J, Li J, Shen Z. Pathologic role of peptidyl-prolyl isomerase Pin1 in pulmonary artery remodeling. Am J Transl Res. 2021 Oct 15;13(10):11162-11177.
[4]Xiaomin Liao , Caixia Wu , Zhongming Shao , Shuya Zhang , Yuan Zou , Keke Wang ,
Yanping Ha , Jingci Xing , Axiu Zheng ,Zhihua Shen, Shaojiang Zheng , Junli Guo , Wei Jie. SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells. Stem Cell Rev Rep,. 2021 Aug;17(4):1374-1389.
[5]Shao Z, Wang K, Zhang S, Yuan J, Liao X, Wu C, Zou Y, Ha Y,Shen Z, Guo J, Jie W. Ingenuity pathway analysis of differentially expressed genes involved in signaling pathways and molecular networks in RhoE gene edited cardiomyocytes. Int J Mol Med. 2020 Sep;46(3):1225-1238.
[6]Shen Z*, Liao X*, Shao Z, Feng M, Yuan J, Wang S, Gan S, Ha Y, He Z, Jie W. Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability.BMC Cancer. 2019 Mar 22;19(1):262.
[7]Ding RR, Yuan JL, Jia YN, Liao XM, Wang SS, Shao ZM, Feng MY, Jie W,Shen ZH#. Epstein-Barr virus-encoded LMP1 regulated Pim1 kinase expression promotes nasopharyngeal carcinoma cells proliferation. Onco Targets Ther. 2019 Feb 11;12:1137-1146.
[8]Zeng Y, Wang S, Feng M, Shao Z, Yuan J,Shen Z, Jie W. [Quantitative proteomics and differential signal enrichment in nasopharyngeal carcinoma cells with or without SETD2 gene knockout]. Nan Fang Yi Ke Da Xue Xue Bao. 2019 Oct 30;39(10):1191-1199.
[9]Wang K, Ding R, Ha Y, Jia Y, Liao X, Wang S, Li R,Shen Z, Xiong H, Guo J, Jie W. Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling. Acta Pharm Sin B. 2018 Sep;8(5):795-804.
[10]封慕茵,郑阿秀,白建荣等.组蛋白甲基化转移酶SETD4对鼻咽癌细胞增殖和迁移的影响[J].中国病理生理杂志,2023,39(02):259-268.
[11]贾亚楠;王可可;王思思;廖晓敏;封慕茵;袁建玲;邵钟铭;揭 伟;申志华#. SATB1高表达促进上皮间叶转化介导鼻咽癌细胞侵袭和转移.中国病理生理杂志, 2018, 34(9): 1578-1585. .
[12]邹园,王思思,伍彩霞,揭伟,申志华. SETD2调控组蛋白甲基转移酶H3K36me3的分子机制及其与肿瘤的关系,广东医科大学学报. 2021,39(01):4-9
[13]李汝佳,袁建玲,贾亚楠,邵钟铭,封慕茵,伍彩霞,邹园,揭伟,申志华.基于TMT标记定量蛋白组学分析SATB1过表达前后鼻咽癌细胞中差异蛋白质及信号富集,中国病理生理杂志. 2020,36(02):346-353
[14]哈艳平,刘晓晓,邵钟铭,邹园,伍彩霞,郭峻莉,申志华,揭伟.低氧刺激通过HIF-1α直接调节Myocardin表达促进骨髓间充质干细胞向心肌样细胞分化,临床与实验病理学杂志. 2021,37(09):1038-1043
[15]邵钟铭,王可可,廖晓敏,哈艳平,李汝佳,申志华,揭伟.低氧诱导c-Kit+骨髓间充质干细胞增殖及旁分泌中ROCK信号的作用,中国组织工程研究. 2019,23(21):3281-3288
[16]王思思,廖晓敏,邵钟铭,袁建玲,封慕茵,哈艳平,李汝佳,申志华,揭伟.基于CRISPR/Cas9技术构建SETD2基因敲除鼻咽癌细胞株并分析其增殖特性,中国病理生理杂志. 2018,34(12):2172-2179
[17]袁建玲,邵钟铭,邹园等.血清反应因子N端片段对鼻咽癌细胞增殖及迁移能力的影响[J].中国病理生理杂志,2022,38(03):535-542.