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赵祖国

2023年09月17日 10:16  点击：[]

赵祖国

EMAIL:zuguozhao@126.com

男，1978年生，医学博士、副教授，2008年毕业于军事医学科学院。现任广东医科大学病原生物学与免疫学研究所副所长，广东医科大学病原生物学专业负责人。广东省预防医学委员会常务理事。研究方向：感染、耐药与免疫。现正采取分子生物学和计算机分子模拟技术，在原子水平上研究细菌的感染和耐药机制。同时采用计算辅助药物设计技术，针对细菌耐药酶关键酶设计抑制性化合物。已指导10名研究生毕业，两人获得“校级优秀毕业生”称号。目前指导在读研究3人。承担国家自然科学基金项目2项，省级科研项目2项，市厅级项目2项，发表论文17篇，其中SCI论文12篇；4项国家发明专利获得授权。获得市级科技奖励二等奖一项。

近年来发表的主要论文：

  1. Biyu Xu, Luguang Liang, Yirong Jiang,Zuguo Zhao*. Investigating the ibrutinib resistance mechanism of L528W mutation on Brutonʼs tyrosine kinase via molecular dynamics simulations. Journal of Molecular Graphics and Modelling. 2024, 126, 108623.

  2. Lv Fei, Weiqi Wang, Yi Luo, Heping Wang, Tingting Zhi, Zhusheng Guo*,Zuguo Zhao*. Genome-Based Analysis of a Multidrug-Resistance HypervirulentKlebsiella pneumoniae. Microbial Drug Resistance.2022,28(8).853-860.DOI: 10.1089/mdr.2021.0307.

  3. Jiaye Tao, Heping Wang, Wenjian Wang, Na Mi, Wei Zhang, Qiujia Wen, Jiajing Ouyang, Xinyun Liang, Min Chen, Wentao Guo, Guoming Li, Jun Liu, Hanning Zhao, Xin Wang, Xuemeng Li, Shengjun Feng,Zuguo Zhao*. Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs.PLOS Computational Biology.2022.06. DOI:10.1371/journal.pcbi.1010343.

  4. Duan J#, Hu C#, Guo J#, Guo L , Sun J ,Zhao Z*. A molecular dynamics study of the complete binding process of meropenem to New Delhi metallo-β-lactamase 1. Physical Chemistry Chemical Physics. 2018, 28; 20(9): 6409-6420.

  5. Lili Jiang, Yunmei Yu, Wei Zeng, Jiafan Guo, Fei Lv, Xin Wang, Xiaoliu, Liu,Zuguo Zhao*. Whole-genome analysis of New Delhi Metallo-Beta-Lactamase-1-producingAcinetobacter haemolyticusfrom China. J Glob Antimicrob Resist. https://doi.org/10.1016/j.jgar.2019.05.012.

  6. Lili Jiang, Youcai Liang, Wei Yao, Juntao Ai, Xin Wang,Zuguo Zhao*. Molecular epidemiology and genetic characterization ofcarbapenem-resistantAcinetobacter baumanniiisolates from Guangdong Province, South China. J Glob Antimicrob Resist, 2018, 17:84-89.

  7. Hua Jin#,Zuguo Zhao#,Qian Lan, Haotong Zhou, Zesen Mai, Yuan Wang, Xiaowen Ding, Jiang Pi, Wenting Zhang, Colin E. Evans and Wenhua Huang. Nasal delivery of hesperidin/chitosan nanoparticles suppress cytokine storm syndrome in lungs of LPS-induced acute lung injury mouse model. Front. Pharmacol.2022,| doi: 10.3389/fphar.2020.592238.

  8. Zu Guo Zhao#, Yun Mei Yu#, Bi Yu Xu, Shuang Shuang Yan, Jun Fa Xu, Fang Liu, Guo Ming Li, Yuan Lin Ding, Shu Qing Wu*. Screening and Anti-virulent Study of N-Acyl Homoserine Lactones DNA Aptamers againstPseudomonas aeruginosaQuorum Sensing. Biotechnology and Bioprocess Engineering. 2013, 18: 406-412.

  9. Jun Liu, Guo-Ming Li, Li-Yao Lin, Xia-Lei Wu, Shao-Long Huang,Yong Zhou,Zu-Guo Zhao*. Association of antibiotic resistance with SHV-12 extended-spectrum β-lactamase inEnterobacter cloacae. Experimental and Therapeutic Medicine. 2016, 11: 269-276.

  10. J Liu, T Zeng, G Su, LY Lin, Y Zhao, WQ Yang, WX Xie,ZG Zhao*, GM Li. The dissemination mode of drug-resistant genes inEnterobacter cloacae. Indian Journal of Medical Microbiology, 2015, 33(Supplement 1): S817-92.

  11. Zu-Guo Zhao#, Shuang-Shuang Yan#, Yun-Mei Yu, Na Mi, La-Xi Zhang, Jun Liu, Xiao-Ling Li, Fang Liu, Jun-Fa Xu, Wei-Qing Yang, Guo-Ming Li*. An Aqueous Extract of Yunnan Baiyao Inhibits the Quorum-Sensing-Related Virulence ofPseudomonas aeruginosa. the Journal of Microbiology. 2013, 51(2): 207-212.

    已授权专利：

  12. 赵祖国;一种可同时识别NDM-1和VIM-2的核酸适体, 2022-06-03,中国, CN201810661632.0 (专利)

  13. 赵祖国;喻云梅;米娜;刘仿;李国明;一种pCr-NHEJ载体及其构建方法及其用于细菌基因定点敲除的应用, 2017-10-19,中国, CN201510097590.9 (专利)

  14. 赵祖国;刘仿;喻云梅;李国明;张腊喜;米娜;许壁榆;晏双双;一种N-(3-氧化十二烷酰基)-L-同型丝氨酸内酯核酸适体及其筛选方法和应用, 2013-3-13,中国, CN201210313778.9 (专利)

  15. 赵祖国;喻云梅;刘仿;李国明;张腊喜;米娜;晏双双;许壁榆;一种新德里金属β内酰胺酶1核酸适体及其筛选方法和应用, 2014-4-16,中国, CN201210314138.X (专利)


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